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KMID : 0608520110170030077
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Korean Journal of Oriental Medicine
2011 Volume.17 No. 3 p.77 ~ p.85
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Development of Prototype for Screening Anti-Inflammation Effects concerning p38 MAPK Signal Pathway
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Kim Chul
Yea Sang-Jun
Nam Ky-Youb
Kim Sang-Kyun
Jnag Hyun-Chul
Kim Jin-Hyun
Kim Young-Eun
Song Mi-Young
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Abstract
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Objectives: The purpose of this study was to develop a simulator which can analyze the anti-inflammatory effects of medical herbs based on e-cell concerning p38 MAPK signal pathway.
Methods: We collected data concerning medical herbs with anti-inflammatory effects and the active compounds to provide as a fundamental databse and to validate the newly developed algorithm. At this time, we used the target database as pubmed and gathered the data by data mining tool, pathwaystudio. Also we have developed the web-based search system for confirming database related to anti-inflammation. We researched the mechanism of actions of proteins in p38 MAPK signal pathway when active compound has been inserted into the network. We reduced total network into TAK-MKK3-p38 and made the two types of mathematical model about active compounds" interaction.
Results and Conclusion : We constructed the database which have 69 cases of medical herbs, 71 cases of active compounds, about 8,000 cases of URL(Uniform Resource Locator) related to papers and reports. We designed the ordinary differential equations for response of TAK, MKK3, p38 in e-cell"s cytosol and nucleus. We used this formular as measure whether an active compound of medicinal plants which is inputted by an user would have an anti-inflammation effects. We developed the visualization program which could show the change of concentration over time.
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KEYWORD
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anti-inflammation, e-cell, p38 MAPK, simulator, Signal pathway
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